Phthalimidoperoxycaproic Acid (PAP): A Radical-Free Whitening Agent

Traditional bleaching agents like hydrogen peroxide are known to cause adverse effects on both soft and hard oral tissues. In contrast, PAP has emerged as a promising alternative due to its gentle yet effective whitening properties.

  • Study Overview: A novel gel formulation containing PAP (referred to as PAP+) was developed and subjected to laboratory testing. The study assessed the effects of six 10-minute exposures to PAP+ compared to commercial carbamide peroxide (CP) and hydrogen peroxide (HP) gels.

  • Key Findings:

    • Enamel Integrity: Unlike HP gels, PAP+ did not cause enamel erosion.

    • Microhardness: Both CP and HP gels reduced enamel microhardness, whereas PAP+ maintained it.

    • Whitening Efficacy: PAP+ outperformed 6% HP in removing complex polyphenol stains, achieving an improvement of approximately eight VITA® Bleachedguide shades after six treatments.

  • Conclusion: The laboratory results support the safety and effectiveness of the PAP+ formulation, suggesting it as a superior alternative to traditional peroxide-based agents.

Reference: Pascolutti, M., & de Oliveira, D. (2021). A Radical-Free Approach to Teeth Whitening. International Journal of Environmental Research and Public Health, 18(23), 12345. Link

 

Back to blog